Mycoplasma genitalium (Mgen)

Mycoplasma genitalium (Mgen)

Find the hidden STI that might be harming your patients

Detect Mgen with the FDA-cleared Aptima® Assay

Mycoplasma genitalium, or Mgen, is a bacterium that can cause cervicitis, pelvic inflammatory disease (PID) and male urethritis. It can coexist with other STIs and cause similar symptoms.

37229-Womens Health-mGen-Hero@2x.jpg37229-Womens Health-mGen-Hero@2x.jpg

Advanced testing amplifies awareness

Recently developed detection capabilities have increased awareness of Mgen as a common STI.

Mgen affects approximately 1% of the general population—occurring more frequently than gonorrhea, but less often than chlamydia1—and it can be highly resistant to standard first-line antibiotics.
Prevalence can be as high as 20% in women who are between 15-25 years old with other STI risk factors2

Mgen can be harmful if left untreated

Detected in up to

30%
of women with clinical cervicitis3
  • Identified in up to 22% of PID cases3
  • Infected patients are 2 times more likely to acquire HIV4
  • Identified in up to 22% of PID cases3
  • Infected patients are 2 times more likely to acquire HIV4

Responsible for

30%
of persistent or recurrent urethritis in men5

Additionally, Mgen coinfection is common in men

  • C trachomatis: 35%6
  • N gonorrhoeae: 14%6
  • C trachomatis and N gonorrheae: 19%6

Additionally, Mgen coinfection is common in men

  • C trachomatis: 35%6
  • N gonorrhoeae: 14%6
  • C trachomatis and N gonorrheae: 19%6

Patients with Mgen can be asymptomatic or can exhibit symptoms that are similar to (or coexist with) other common STIs

Diagnose the cause of patients’ symptoms and reduce negative outcomes associated with untreated infections with one test.

Symptoms

  • Frequent urination
  • Abnormal vaginal or penile discharge
  • Vaginal irritation or itching
  • Pain during intercourse
  • Burning during urination
  • Abnormal vaginal bleeding between periods or after intercourse

Suspected pathogens

  • Chlamydia
  • Gonorrhea
  • Trichomoniasis
  • Mgen

One specimen

STI panels test for all 4 pathogens with 1 urogenital samplea

aSTI panels can be performed with any of the collection devices shown above.

Mgen requires specific treatment and can be harmful if left untreated

Although STIs present with similar symptoms, each responds better to different medications. Mgen can be highly resistant to standard first-line antibiotics, in which case, other medications may be necessary to avoid serious complications.

Get the answers you and your patients need with 1 test from Quest

FDA-cleared Aptima Assay from Quest uses nucleic acid amplification testing (NAAT), the preferred method of detection per the CDC.7

Test name

Test code

TEST NAME

Mycoplasma genitalium, rRNA, TMA, PCR

TEST CODE

91475

TEST NAME

Sexually Transmitted Infections (STIs) Cervicitis Panel

Includes Chlamydia/Neisseria gonorrhoeae RNA, TMA, Urogenital (11363); SureSwab®, Trichomonas vaginalis RNA, Qualitative, TMA (19550); Mycoplasma genitalium, rRNA, TMA (91475)

TEST CODE

36962

TEST NAME

Sexually Transmitted Infections (STIs) Pelvic Inflammatory Disease (PID) Panel

Includes Chlamydia/Neisseria gonorrhoeae RNA, TMA, Urogenital (11363); SureSwab®, Trichomonas vaginalis RNA, Qualitative, TMA (19550); Mycoplasma genitalium, rRNA, TMA (91475)

TEST CODE

36965

TEST NAME

Sexually Transmitted Infections (STIs) Male Urethritis Panel

Includes Chlamydia/Neisseria gonorrhoeae RNA, TMA, Urogenital (11363); Trichomonas vaginalis RNA, Qualitative, TMA, Males (90801); Mycoplasma genitalium, rRNA, TMA (91475)

TEST CODE

36964

TEST NAME

Sexually Transmitted Infections (STIs) Male Urethritis Panel Expanded

Includes Chlamydia/Neisseria gonorrhoeae RNA, TMA, Urogenital (11363); Trichomonas vaginalis RNA, Qualitative, TMA, Males (90801); Mycoplasma genitalium, rRNA, TMA (91475); SureSwab®, Ureaplasma species, Real-Time PCR (91476)

TEST CODE

38288

All components of panels can be ordered separately: C trachomatis (test code 11361); N gonorrhoeae (test code 11362); C trachomatis/N gonorrhoeae (test code 11363); trichomoniasis (test code 19550); Ureaplasma species (test code 91476).

Visit the test directory to order the right test for your patients today

Test codes may vary by location. Please contact your local laboratory for more information.

​References:

  1. Manhart LE, Holmes KK, Hughes JP, et al. Mycoplasma genitalium among young adults in the United States: an emerging sexually transmitted infection. Am J Public Health. 2007;97(6):1118-1125. doi:10.2105/AJPH.2005.074062
  2. Seña AC, Lee JY, Schwebke J, et al. A silent epidemic: the prevalence, incidence and persistence of Mycoplasma genitalium among young, asymptomatic high-risk women in the United States. Clin Infect Dis. 2018;67(1):73-79. doi: 10.1093/cid/ciy025
  3. CDC. Sexually Transmitted Infections Treatment Guidelines, 2021. Mycoplasma genitalium. Published July 22, 2021. Accessed September 13, 2021. https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm
  4. Napierala Mavedzenge S, Weiss HA. Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis. AIDS. 2009;23(5):611-620. doi:10.1097/QAD.0b013e328323da3e
  5. Ronda J, Gaydos CA, Perin J, et al Does the Sex Risk Quiz predict Mycoplasma genitalium infection in urban adolescents and young adult women? Sex Transm Dis. 2018;45(11):728-734.doi:10.1097/OLQ
  6. Mena L, Wang X, Mroczkowski TF, et al. Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. Clin Infect Dis. 2002 Nov 15;35(10):1167-73. doi: 10.1086/343829
  7. Workowski KA, Bolan GA. CDC. Sexually transmitted diseases treatment guidelines, 2015. [published correction appears in MMWR Recomm Rep. 2015;64(33):924]. MMWR Recomm Rep. 2015;64(RR-03):1-137